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The standard plate test and preincubation test - both with and without metabolic activation liver S9 mix from induced rats - were performed. The test substance is not mutagenic in Salmonella typhimurium under test conditions chosen in this study.Dartmouth 2021 lacrosse commits
In a mammalian cell cytogenetics chromosome aberration assay Hilliard, CHO cell cultures were exposed to Ephedrine sulfate at concentrations of 0 ; 6 ; 8 and 10 mM with and without metabolic activation for 3 hours and were examined for structural chromosome changes after 20 hours. In both independent experiments, neither a significant nor a biologically relevant increase in the number of cells carrying structural chromosomal aberrations was observed after treatment with the test item.
Thus, Ephedrine sulfate was negative in two aberration tests with and without S-9 activation in CHO cells. Moderate cytotoxicity up to the maximum dose of 10 mM was observed. In a mouse lymphoma assay McGregor,using the LY thymidine kinase locus the mutagenic potential of the read across substance - -Ephedrine was tested at concentrations of 1. The study demonstrated that the test substance was inactive and showed no mutagenic potential. Information on Registered Substances comes from registration dossiers which have been assigned a registration number.
This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner s of the respective information might violate the rights of the owner. EC number: CAS number: Ecotoxicological Summary Aquatic toxicity Endpoint summary Short-term toxicity to fish Long-term toxicity to fish Short-term toxicity to aquatic invertebrates Long-term toxicity to aquatic invertebrates Toxicity to aquatic algae and cyanobacteria Toxicity to aquatic plants other than algae Toxicity to microorganisms Endocrine disrupter testing in aquatic vertebrates — in vivo Toxicity to other aquatic organisms Sediment toxicity Terrestrial toxicity Endpoint summary Toxicity to soil macroorganisms except arthropods Toxicity to terrestrial arthropods Toxicity to terrestrial plants Toxicity to soil microorganisms Toxicity to birds Toxicity to other above-ground organisms Biological effects monitoring Biotransformation and kinetics Additional ecotoxological information.
Administrative data Key value for chemical safety assessment Additional information Justification for classification or non-classification. CA : In a mammalian cell cytogenetics chromosome aberration assay Hilliard, CHO cell cultures were exposed to Ephedrine sulfate at concentrations of 0 ; 6 ; 8 and 10 mM with and without metabolic activation for 3 hours and were examined for structural chromosome changes after 20 hours. MLA: In a mouse lymphoma assay McGregor,using the LY thymidine kinase locus the mutagenic potential of the read across substance - -Ephedrine was tested at concentrations of 1.
Justification for selection of genetic toxicity endpoint No study was selected, since all tests were negative. All tests were negative. Endpoint Conclusion: No adverse effect observed negative.Ephedrine is a medication and stimulant.
Common side effects include trouble sleeping, anxiety, headache, hallucinationshigh blood pressurefast heart rateloss of appetite, and inability to urinate. Ephedrine was first isolated in and came into commercial use in Both ephedrine and pseudoephedrine increase blood pressure and act as bronchodilatorswith pseudoephedrine having considerably less effect. Ephedrine may decrease motion sicknessbut it has mainly been used to decrease the sedating effects of other medications used for motion sickness.
Ephedrine promotes modest short-term weight loss specifically fat loss, but its long-term effects are unknown. Ephedrine also decreases gastric emptying. Methylxanthines such as caffeine and theophylline have a synergistic effect with ephedrine with respect to weight loss.
This led to creation and marketing of compound products.Minecraft beach house
It is a popular supplement taken by bodybuilders seeking to cut body fat before a competition. Because of ephedrine's structural similarity to methamphetamine, it can be used to create methamphetamine using chemical reduction in which ephedrine's hydroxyl group is removed; this has made ephedrine a highly sought-after chemical precursor in the illicit manufacture of methamphetamine. The most popular method for reducing ephedrine to methamphetamine is similar to the Birch reductionin that it uses anhydrous ammonia and lithium metal in the reaction.
The second-most popular method uses red phosphorus and iodine in the reaction with ephedrine. Moreover, ephedrine can be synthesized into methcathinone via simple oxidation. Ephedrine may be quantified in blood, plasma, or urine to monitor possible abuse by athletes, confirm a diagnosis of poisoning, or assist in a medicolegal death investigation.
Many commercial immunoassay screening tests directed at the amphetamines cross-react appreciably with ephedrine, but chromatographic techniques can easily distinguish ephedrine from other phenethylamine derivatives. Ephedrine should not be used in conjunction with certain antidepressants, namely norepinephrine-dopamine reuptake inhibitors NDRIsas this increases the risk of symptoms due to excessive serum levels of norepinephrine.
Bupropion is an example of an antidepressant with an amphetamine-like structure similar to ephedrine, and it is an NDRI. Its action bears more resemblance to amphetamine than to fluoxetine in that its primary mode of therapeutic action involves norepinephrine and to a lesser degree dopamine, but it also releases some serotonin from presynaptic clefts.
It should not be used with ephedrine, as it may increase the likelihood of side effects. Contraindications for the use of ephedrine include: closed-angle glaucomaphaeochromocytomaasymmetric septal hypertrophy idiopathic hypertrophic subaortic stenosisconcomitant or recent previous 14 days monoamine oxidase inhibitor MAOI therapy, general anaesthesia with halogenated hydrocarbons particularly halothanetachyarrhythmias or ventricular fibrillation, or hypersensitivity to ephedrine or other stimulants.
Ephedrine should not be used at any time during pregnancy unless specifically indicated by a qualified physician and only when other options are unavailable. Ephedrine is a potentially dangerous natural compound; as of [update] the US Food and Drug Administration had received over 18, reports of adverse effects in people using it.
Adverse drug reactions ADRs are more common with systemic administration e. ADRs associated with ephedrine therapy include: . The neurotoxicity of l-ephedrine is disputed. In chemical synthesisephedrine is used in bulk quantities as a chiral auxiliary group.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Skip to Content. Category: Decongestant, nasal systemic — Indications Accepted Congestion, nasal treatment Congestion, sinus treatment or Congestion, eustachian tube treatment —Pseudoephedrine is indicated for temporary relief of congestion associated with acute coryza, acute eustachian salpingitis, serous otitis media with eustachian tube congestion, vasomotor rhinitisand aerotitis barotitis media.
Pseudoephedrine also may be indicated as an adjunct to analgesics, antihistamines, antibiotics, antitussives, or expectorants for optimum results in allergic rhinitiscroup, acute and subacute sinusitis, acute otitis media, and acute tracheobronchitis. The medication shrinks swollen nasal mucous membranes; reduces tissue hyperemia, edema, and nasal congestion; and increases nasal airway patency. Also, drainage of sinus secretions may be increased and obstructed eustachian ostia may be opened.
Biotransformation: Pseudoephedrine is incompletely metabolized in the liver. Onset of action: 15 to 30 minutes. Time to peak effect: Within 30 to 60 minutes. Duration of action: Tablets, oral solution, and syrup—3 to 4 hours. Extended-release capsules and tablets—8 to 12 hours. The rate of excretion is accelerated in acidic urine. Studies in animals have not shown that pseudoephedrine causes teratogenic effects in the fetus. However, pseudoephedrine reduced average weight, length, and rate of skeletal ossification in the animal fetus.
Geriatrics No information is available on the relationship of age to the effects of pseudoephedrine in geriatric patients. However, elderly patients are more likely to have age-related prostatic hypertrophy, which may require adjustment of dosage in patients receiving pseudoephedrine.
Charcoal is useful only if administered within 1 hour. However, if an extended-release preparation was taken, there will be more time for benefit from these measures.
To enhance elimination: Forced diuresis will increase elimination of pseudoephedrine provided renal function is adequate; however, diuresis is not recommended for severe overdosage. Specific treatment: For delirium or convulsions, intravenous diazepam may be administered. The cardiac state should be monitored and serum electrolytes measured. If there are signs of cardiac toxicity, intravenous propranolol may be indicated. Hypokalemia may be treated, if necessary, with a slow infusion of a dilute potassium chloride solution; serum potassium concentration should be monitored during and for several hours after administration of potassium chloride.Medically reviewed by Drugs.
Last updated on May 5, Used parenterally for treatment of clinically important hypotension in the setting of anesthesia. Although ephedrine historically considered the vasopressor of choice in obstetric anesthesia, some evidence suggests that phenylephrine may provide more favorable fetal acid-base balance. IM use of ephedrine also evaluated in this setting; however, results have been equivocal. Used orally as a bronchodilator for symptomatic treatment of asthma.
Used in fixed-combination with guaifenesin as self-medication for the temporary relief of mild symptoms of intermittent asthma e. Use of an OTC bronchodilator may be appropriate in patients with mild symptoms of intermittent asthma; however, those with more severe asthma i.
While oral ephedrine was once widely used in the treatment of asthma, the drug generally has been replaced by more selective and rapid-acting agents e. Dietary supplements containing ephedrine alkaloids are no longer commercially available in the US. Has been used as a nasal decongestant, but of doubtful value when used for this condition. Ephedrine has been used in clandestine synthesis of methamphetamine and methcathinone.
Administer orally as a fixed-combination preparation. Administer by IV injection. Vials are for single-use only; discard unused portions. Available as ephedrine hydrochloride or ephedrine sulfate; dosage expressed in terms of the salt. Ephedrine sulfate: Usual dose of 0. Ephedrine sulfate: Initially, 5—10 mg by IV bolus injection; administer additional bolus doses as needed up to a total dose of 50 mg to achieve desired BP response.
Other IV dosage regimens have been recommended. Ephedrine sulfate: Usual dose of 25—50 mg has been administered. Ephedrine hydrochloride or sulfate self-medication : Ephedrine sulfate: Parenteral doses of Ephedrine hydrochloride or sulfate self-medication : Maximum mg in any hour period. For self-medication in asthma: Concurrent or recent i. Known hypersensitivity to ephedrine or sympathomimetic drugs.
May cause hypertension and tachycardia; risk of serious adverse effects e. Serious postpartum hypertension, in some cases resulting in stroke, reported in patients receiving a vasopressor e. Increased risk of hypertension in patients receiving ephedrine sulfate injection for prevention of hypotension.
Risk of anginal pain in patients with coronary insufficiency or ischemic heart disease. Caution in patients with cardiovascular disease e. Tolerance and tachyphylaxis may develop with repeated parenteral administration; in some cases; effectiveness may return after the drug is withheld temporarily. If used for treatment of hypotension during anesthesia, consider possibility of tachyphylaxis and be prepared to use an alternative vasopressor.
Use with caution in patients with cardiovascular disease, hypertension, angina, hyperthyroidism, diabetes mellitus, or prostatic hyperplasia.
Use for self-medication for bronchospasm only if previously diagnosed with asthma; do not use if previously hospitalized for asthma unless directed by a clinician. Dietary supplements containing ephedrine alkaloids have been associated with serious adverse cardiac effects e.For discussion around the best bets for each event we have a very friendly and busy sports betting tips forum.
Head here if you want to ask questions to tipsters or to share your opinions too on what are the best betting opportunities today. Some people like to read longer article style betting previews. If that is you, then we have an excellent blogs section at OLBG where our expert tipsters preview many of the popular events.
As well as event previews they also share valuable information on betting strategy. Check out the OLBG Sports Betting Blogs. This page provides a list of the most popular betting tips today according to the combined wisdom of the OLBG tipster community. COMLast 4 Vip Matches. Be part of this offer. Our archives are real and all matches goes to our archive.
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With respect from our team Thank you Question: WHAT PAYMENT METHODS DO WE ACCEPT. Answer: Payment services for transfer money accepted: Western Union. ARE THERE MORE BENEFITS. We can give you better deal if you are interested in buying minimum two months of premium picks. Question: CAN I REQUEST FREE TRIAL TIPS. Due to all respect for our customets we dont give free tips to any others people because all of them just want the games and after that they dont wanna pay.
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Very well analyzed matches, the risks are very low and the odds are actually very good. I've been with them for a while now and they have always provided me with nice sure tips that always win. That is very good for me, cause it gives great morale knowing that every day you have at least one prediction that always wins. I have to say that this is the first service of it's kind. I have been betting for a lot of time and was really looking for a service like this.You can reliably connect multiple iOS devices to Photoshop using USB or over Wi-Fi.
If you have a document with artboards, Device Preview attempts to show you the correct artboard by matching the size and position of the artboard with the size of the connected device. You can also use the navigation bar to preview a specific artboard on the device or swipe through artboards that have matching widths. Connect multiple iOS devices to Photoshop via USB or over WiFi.
Creative Cloud seamlessly pairs your devices with Photoshop. Note: If you're unable to see a device listed in the Device Preview dialog while connecting it, click Check For Devices. Note: Having trouble connecting to your device.
See Troubleshooting Device Preview connectivityOnce the connection has been successfully established, the Device Preview panel in Photoshop displays the name of the connected device. Any changes you now make to the design in Photoshop are reflected in the preview on the device. When you rotate your device, the content being previewed is rotated automatically.
Note: While connecting to Photoshop for the first time, Preview CC requires that the Device Preview panel in Photoshop is open. If you're unable to see a device listed in the Device Preview dialog while connecting it, click Check For Devices.
You can swipe to navigate between different artboards and preview them on actual devices. For example, you can preview an iPhone artboard on an iPhone while simultaneously previewing a larger version of that artboard on an iPad, reducing the time required to test designs on multiple screens. Preview CC automatically selects and displays the appropriate artboard based on the device screen size. Preview CC works with Photoshop CC 2015, which is available as a free update for Creative Cloud members.Schweppes tonic water cans
You can download Photoshop CC 2015 as an update via the Creative Cloud desktop app. See this Help article to learn how to install or upgrade to Photoshop CC 2015. Adobe Preview CC FAQ answers several other frequently-asked questions about Preview CC. The information on this page is relevant to earlier versions of Photoshop. Connect Preview CC with Photoshop Connect multiple iOS devices to Photoshop via USB or over WiFi.
See Troubleshooting Device Preview connectivity Once the connection has been successfully established, the Device Preview panel in Photoshop displays the name of the connected device.
Check for devices If you're unable to see a device listed in the Device Preview dialog while connecting it, click Check For Devices. Check For Devices when no devices are connected Check for devices when a device is already connected Support for artboards You can swipe to navigate between different artboards and preview them on actual devices.
Common questions Is Preview CC available for Android. Preview CC is not yet available for Android.Neopixel protocol
Which version of Photoshop CC does Preview CC work with. Which devices does Preview CC support.We even have odds so that you can compare them against the stats at a glance to see if they provide value. We make every single one of these data public through our API and CSVs which will be available later this year. We encourage you to use our data to do your own soccer stats analysis such as machine learning and model based predictions. Shots and posession data will be available later this year as well.
Other stats services update once a week, or once a day. We update within 10 minutes of matches ending and our users love us for it. We're also continually working to update our stats at an even faster rate. Our aim is to update our stats every 2 minutes in the future.
History is the best predicting indicator of our future. Whatever patterns that happened in the past usually happens in the present. We believe that by using our statistics for your football predictions, you have a much better chance of getting them right. There are no other services that have as much of a complete data as we do for making assumptions about what the match outcome is going to be for today's matches.
For example if Manchester United has scored over 1. Stats enable intelligent, and correct football predictions.
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